Endocrine Abstracts

Objective: To assess the outcome of medical and ablative therapies in amiodarone-induced thyrotoxicosis (AIT).Subjects and methods: Seventy patients (32 M/38 F, aged 59.7±1.4 years) with AIT (24-type 1, 20-type 2 and 26-mixed forms) were followed-up 13.4±2.3 months. TSH was measured by immunoradiometric assay, TT3 and TT4 by chemiluminescence.Results: Antithyroid drugs (ATD) were used as single thera...

Moderately elevated plasma homocysteine levels (>12 μmol/l) are highly prevalent in the general population and are associated with an increased risk for cardiovascular disease. Homocysteine is an amino acid produced during catabolism of the essential amino acid methionine. Metabolism of homocysteine requires an adequate supply of folic acid, vitamin B12 and vitamin B6.Moderate hyperhomocysteinemia may be caused by a variety of factors: chronic d...

Introduction: Even mild to moderate maternal iodine deficiency during pregnancy is associated with impaired child cognition. Iodine deficiency is especially problematic in pregnant women, who have a higher iodine requirement (250 μg/day) than non-pregnant women (150 μg/day).Objective: To assess iodine status (median urinary iodine concentration, UIC) in pregnant women from multiple endemic or non-endemic areas in Romania, 13 years after impleme...